First TEAM

Methods of non-stationary signal processing for more sensitive NMR spectroscopy

The goal of the project is to propose a novel treatment of the data from serial Nuclear Magnetic Resonance (NMR) experiments. Since NMR spectroscopy is one of the main analytical tools for chemistry and structural biology (but also physics, medicine and many others) its improvement is of crucial importance. In particular, efforts aimed at enhancing a low sensitivity, one of the main limitations of NMR, are worth undertaking. The toolbox developed in the frame of this project will contain data processing algorithms providing many-fold sensitivity gain in serial NMR measurements. Alternatively, they can be used to boost a speed of measurements, which is very important, since NMR experiments are often days-long.

The project started in July 2018. So far, we published the following research:

 

New Article in ChemComm

Resolution enhancement in NMR spectra by deconvolution with compressed sensing reconstruction  Krzysztof Kazimierczuk, Paweł Kasprzak, Panagiota S. Georgoulia, Irena Matečko-Burmann,

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New Article in Chemistry a European Journal

Temperature as an Extra Dimension in Multidimensional Protein NMR Spectroscopy Dr. Alexandra Shchukina, Paweł Małecki, Dr. Borja Mateos, Dr. Michał

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New Article in Magnetic Resonance in Chemistry

Benefits of time‐resolved nonuniform sampling in reaction monitoring: The case of aza‐Michael addition of benzylamine and acrylamide Dariusz Gołowicz, Magdalena

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New Article in Angewandte Chemie

Non‐stationary complementary non‐uniform sampling (NOSCO NUS) for fast acquisition of serial 2D NMR titration data Javier Agustin Romero, Ewa Klaudia Nawrocka,

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New Article in PLOS

Restriction of S-adenosylmethionine conformational freedom by knotted protein binding sites Agata P. Perlinska, Adam Stasiulewicz, Ewa K. Nawrocka, Krzysztof Kazimierczuk,

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New Article in Sensors

Enhancing Compression Level for More Efficient Compressed Sensing and Other Lessons from NMR Spectroscopy Dariusz Gołowicz, Paweł Kasprzak and Krzysztof

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New Article in Progress in NMR Spectroscopy

Fast time-resolved NMR with non-uniform sampling Dariusz Gołowicz, Paweł Kasprzak,  Vladislav Orekhov and Krzysztof Kazimierczuk* NMR spectroscopy is a versatile tool

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New Article in Analytical Chemistry

Non-stationary 2D NMR – a novel method for studying reaction mechanism in situ. Ewa K. Nawrocka, Paweł Kasprzak, Katarzyna Zawada,

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New Article in Physical Chemistry Chemical Physics

Quick temperature-swept pure-shift NMR: case of solvent effects in atorvastatin Małgorzata Rytel, Paweł Kasprzak, Piotr Setny and Krzysztof Kazimierczuk Pure-shift

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logotypes: European funds, Republic of Poland, Foundation for Poish Science, European Union